Heterocyclic compounds are widely distributed in nature and are essential for life. Many heterocyclic compounds due to their specific activity are employed in the treatment of many diseases. Heterocyclic compounds exhibit variety of biological activities. Benzothiazoles are well established in literature as important biologically active heterocyclic compounds. Benzothiazoles play a leading role in the treatment of a variety of bacterial and fungal infections. Benzothiazole contain a phenyl ring fused at 4,5 position of thiazole moiety. Thiazole is the biologically active part of benzothiazole moiety. In the present work, a series of some new substituted benzothiazole derivatives (IVa-IVl) were synthesized from substituted benzophenone (IIa-IIb) in the presence of substituted 2-aminobenzothiazoles (Ia-If) using acetonitrile as solvent. All the synthesized compounds were characterized by TLC, melting point determination, IR, 1H NMR and mass spectral studies. All the synthesized compounds were screened in-vitro for their antibacterial and antifungal activity against representative strains of potent pathogenic bacteria (Staphylococcus aureus and Escherichia coli) and fungi (Aspergillus niger and Candida albicans). Some of the compounds displayed pronounced biological activity
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